I thought of the same thing: Going out a bit further than Pleiades or Barny's Loop. I think the Lagoon Nebula or the Omega Nebula would be a good spot because it has a crossroads function so to say. You can aim further for the Core, the Neutron Fields or go 'east' or 'west' along the inner spiral arms from there.
In this universe there are only three conditions for you: You are either part of the solution, part of the problem or part of the landscape. This system is accompanied by only two choices: You accept it or you change it.