the main issue will be most likely money. (for some)
i have a python stashed away a anaconda rigged for trading and 67 odd million credits. Now it took an awfull lot of grinding and now the grind gets a lot harder for people who are not there yet, or (like me) want/have to grind even more.
In 1.1 the endless stream of pirates in RES will get nerfed too (i do not know of changing instance with log out/log in will reset it) but that was the most viable way next to trading to make money imho.